UnivTrevesV1, Main, Exploration, bibRecord, 000836

Secondary genetic lesions in acute myeloid leukemia with inv(16) or t(16;16): a study of the German-Austrian AML Study Group (AMLSG)

Identifieur interne : 000836 ( Main/Exploration ); précédent : 000835; suivant : 000837

Secondary genetic lesions in acute myeloid leukemia with inv(16) or t(16;16): a study of the German-Austrian AML Study Group (AMLSG)

Auteurs : Peter Paschka [Allemagne] ; JUAN DU [Allemagne] ; Richard F. Schlenk [Allemagne] ; Verena I. Gaidzik [Allemagne] ; Lars Bullinger [Allemagne] ; Andrea Corbacioglu [Allemagne] ; Daniela Sp Th [Allemagne] ; Sabine Kayser [Allemagne] ; Brigitte Schlegelberger [Allemagne] ; Jürgen Krauter [Allemagne] ; Arnold Ganser [Allemagne] ; Claus-Henning Köhne [Allemagne] ; Gerhard Held [Allemagne] ; Marie Von Lilienfeld-Toal [Allemagne] ; Heinz Kirchen [Allemagne] ; Mathias Rummel [Allemagne] ; Katharina Götze [Allemagne] ; Heinz-August Horst [Allemagne] ; Mark Ringhoffer [Allemagne] ; Michael Lübbert [Allemagne] ; Mohammed Wattad [Allemagne] ; Helmut R. Salih [Allemagne] ; Andrea Kündgen [Allemagne] ; Hartmut Döhner [Allemagne] ; Konstanze Döhner [Allemagne]

Source :

Blood [ 0006-4971 ] ; 2012.

RBID : Pascal:13-0077361

Descripteurs français

Pascal (Inist)
- Secondaire, Génétique, Lésion, Leucémie aiguë myéloblastique, Allemagne, Hématologie.
Wicri :
- geographic : Allemagne.
- topic : Génétique.

English descriptors

KwdEn :
- Acute myelogenous leukemia, Genetics, Germany, Hematology, Lesion, Secondary.

Abstract

In this study, we evaluated the impact of secondary genetic lesions in acute myeloid leukemia (AML) with inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBFB-MYH11. We studied 176 patients, all enrolled on prospective treatment trials, for secondary chromosomal aberrations and mutations in N-IKRAS, KIT, FLT3, and JAK2 (V617F) genes. Most frequent chromosomal aberrations were trisomy 22 (18%) and trisomy 8 (16%). Overall, 84% of patients harbored at least 1 gene mutation, with RAS being affected in 53% (45% NRAS; 13% KRAS) of the cases, followed by KIT(37%) and FLT3(17%; FLT3-TKD [14%], FLT3-ITD [5%]). None of the secondary genetic lesions influenced achievement of complete remission. In multivariable analyses, KIT mutation (hazard ratio [HR] = 1.67; P = .04]_, log₁₀(WBC) (HR = 1.33; P = .02), and trisomy 22 (HR = 0.54; P = .08) were relevant factors for relapse-free survival; for overall survival, FLT3 mutation (HR = 2.56; P = .006), trisomy 22 (HR = 0.45; P = .07), trisomy 8 (HR = 2.26; P = .02), age (difference of 10 years, HR = 1.46; P = .01), and therapy-related AML (HR = 2.13; P = .14) revealed as prognostic factors. The adverse effects of KIT and FLT3 mutations were mainly attributed to exon 8 and tyrosine kinase domain mutations, respectively. Our large study emphasizes the impact of both secondary chromosomal aberrations as well as gene mutations for outcome in AML with inv(16)/t (16;16).

Affiliations:

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Le document en format XML

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<author><name sortKey="Von Lilienfeld Toal, Marie" sort="Von Lilienfeld Toal, Marie" uniqKey="Von Lilienfeld Toal M" first="Marie" last="Von Lilienfeld-Toal">Marie Von Lilienfeld-Toal</name>
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<author><name sortKey="Dohner, Konstanze" sort="Dohner, Konstanze" uniqKey="Dohner K" first="Konstanze" last="Döhner">Konstanze Döhner</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Universitätsklinikum Ulm</s1>
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<country>Allemagne</country>
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<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Ulm</settlement>
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<date when="2012">2012</date>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Secondary genetic lesions in acute myeloid leukemia with inv(16) or t(16;16): a study of the German-Austrian AML Study Group (AMLSG)</title>
<author><name sortKey="Paschka, Peter" sort="Paschka, Peter" uniqKey="Paschka P" first="Peter" last="Paschka">Peter Paschka</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Universitätsklinikum Ulm</s1>
<s2>Ulm</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Ulm</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Juan Du" sort="Juan Du" uniqKey="Juan Du" last="Juan Du">JUAN DU</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Universitätsklinikum Ulm</s1>
<s2>Ulm</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Ulm</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schlenk, Richard F" sort="Schlenk, Richard F" uniqKey="Schlenk R" first="Richard F." last="Schlenk">Richard F. Schlenk</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Universitätsklinikum Ulm</s1>
<s2>Ulm</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Ulm</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gaidzik, Verena I" sort="Gaidzik, Verena I" uniqKey="Gaidzik V" first="Verena I." last="Gaidzik">Verena I. Gaidzik</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Universitätsklinikum Ulm</s1>
<s2>Ulm</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Ulm</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bullinger, Lars" sort="Bullinger, Lars" uniqKey="Bullinger L" first="Lars" last="Bullinger">Lars Bullinger</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Universitätsklinikum Ulm</s1>
<s2>Ulm</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Ulm</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Corbacioglu, Andrea" sort="Corbacioglu, Andrea" uniqKey="Corbacioglu A" first="Andrea" last="Corbacioglu">Andrea Corbacioglu</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Universitätsklinikum Ulm</s1>
<s2>Ulm</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Ulm</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sp Th, Daniela" sort="Sp Th, Daniela" uniqKey="Sp Th D" first="Daniela" last="Sp Th">Daniela Sp Th</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Universitätsklinikum Ulm</s1>
<s2>Ulm</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Ulm</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kayser, Sabine" sort="Kayser, Sabine" uniqKey="Kayser S" first="Sabine" last="Kayser">Sabine Kayser</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Universitätsklinikum Ulm</s1>
<s2>Ulm</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Ulm</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schlegelberger, Brigitte" sort="Schlegelberger, Brigitte" uniqKey="Schlegelberger B" first="Brigitte" last="Schlegelberger">Brigitte Schlegelberger</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Medizinische Hochschule Hannover</s1>
<s2>Hannover</s2>
<s3>DEU</s3>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="2">Basse-Saxe</region>
<settlement type="city">Hanovre</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Krauter, Jurgen" sort="Krauter, Jurgen" uniqKey="Krauter J" first="Jürgen" last="Krauter">Jürgen Krauter</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Medizinische Hochschule Hannover</s1>
<s2>Hannover</s2>
<s3>DEU</s3>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="2">Basse-Saxe</region>
<settlement type="city">Hanovre</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ganser, Arnold" sort="Ganser, Arnold" uniqKey="Ganser A" first="Arnold" last="Ganser">Arnold Ganser</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Medizinische Hochschule Hannover</s1>
<s2>Hannover</s2>
<s3>DEU</s3>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="2">Basse-Saxe</region>
<settlement type="city">Hanovre</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kohne, Claus Henning" sort="Kohne, Claus Henning" uniqKey="Kohne C" first="Claus-Henning" last="Köhne">Claus-Henning Köhne</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Klinikum Oldenburg</s1>
<s2>Oldenburg</s2>
<s3>DEU</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Oldenburg</wicri:noRegion>
<wicri:noRegion>Klinikum Oldenburg</wicri:noRegion>
<wicri:noRegion>Klinikum Oldenburg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Held, Gerhard" sort="Held, Gerhard" uniqKey="Held G" first="Gerhard" last="Held">Gerhard Held</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Universitätsklinikum des Saarlandes</s1>
<s2>Homburg</s2>
<s3>DEU</s3>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Homburg</wicri:noRegion>
<wicri:noRegion>Universitätsklinikum des Saarlandes</wicri:noRegion>
<wicri:noRegion>Universitätsklinikum des Saarlandes</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Von Lilienfeld Toal, Marie" sort="Von Lilienfeld Toal, Marie" uniqKey="Von Lilienfeld Toal M" first="Marie" last="Von Lilienfeld-Toal">Marie Von Lilienfeld-Toal</name>
<affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Universitätsklinikum Bonn</s1>
<s2>Bonn</s2>
<s3>DEU</s3>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kirchen, Heinz" sort="Kirchen, Heinz" uniqKey="Kirchen H" first="Heinz" last="Kirchen">Heinz Kirchen</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Krankenhaus der Barmherzigen Brüder</s1>
<s2>Trier</s2>
<s3>DEU</s3>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Trier</wicri:noRegion>
<wicri:noRegion>Krankenhaus der Barmherzigen Brüder</wicri:noRegion>
<wicri:noRegion>Krankenhaus der Barmherzigen Brüder</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rummel, Mathias" sort="Rummel, Mathias" uniqKey="Rummel M" first="Mathias" last="Rummel">Mathias Rummel</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Universitätsklinikum Giessen und Marburg</s1>
<s2>Giessen</s2>
<s3>DEU</s3>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Giessen</wicri:noRegion>
<wicri:noRegion>Universitätsklinikum Giessen und Marburg</wicri:noRegion>
<wicri:noRegion>Universitätsklinikum Giessen und Marburg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gotze, Katharina" sort="Gotze, Katharina" uniqKey="Gotze K" first="Katharina" last="Götze">Katharina Götze</name>
<affiliation wicri:level="4"><inist:fA14 i1="08"><s1>Klinikum rechts der Isar der Technischen Universität München</s1>
<s2>München</s2>
<s3>DEU</s3>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
<orgName type="university">Université Louis-et-Maximilien de Munich</orgName>
</affiliation>
</author>
<author><name sortKey="Horst, Heinz August" sort="Horst, Heinz August" uniqKey="Horst H" first="Heinz-August" last="Horst">Heinz-August Horst</name>
<affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Universitätsklinikum Schleswig-Holstein</s1>
<s2>Kiel</s2>
<s3>DEU</s3>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="2">Schleswig-Holstein</region>
<settlement type="city">Kiel</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ringhoffer, Mark" sort="Ringhoffer, Mark" uniqKey="Ringhoffer M" first="Mark" last="Ringhoffer">Mark Ringhoffer</name>
<affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Städtisches Klinikum Karlsruhe</s1>
<s2>Karlsruhe</s2>
<s3>DEU</s3>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Karlsruhe</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lubbert, Michael" sort="Lubbert, Michael" uniqKey="Lubbert M" first="Michael" last="Lübbert">Michael Lübbert</name>
<affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Universitätsklinikum Freiburg</s1>
<s2>Freiburg</s2>
<s3>DEU</s3>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Fribourg-en-Brisgau</region>
<settlement type="city">Fribourg-en-Brisgau</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wattad, Mohammed" sort="Wattad, Mohammed" uniqKey="Wattad M" first="Mohammed" last="Wattad">Mohammed Wattad</name>
<affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Kliniken Essen Sued</s1>
<s2>Essen</s2>
<s3>DEU</s3>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Essen</wicri:noRegion>
<wicri:noRegion>Kliniken Essen Sued</wicri:noRegion>
<wicri:noRegion>Kliniken Essen Sued</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Salih, Helmut R" sort="Salih, Helmut R" uniqKey="Salih H" first="Helmut R." last="Salih">Helmut R. Salih</name>
<affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Universitätsklinikum Tübingen</s1>
<s2>Tübingen</s2>
<s3>DEU</s3>
<sZ>22 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Tübingen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kundgen, Andrea" sort="Kundgen, Andrea" uniqKey="Kundgen A" first="Andrea" last="Kündgen">Andrea Kündgen</name>
<affiliation wicri:level="3"><inist:fA14 i1="14"><s1>Universitätsklinikum Düsseldorf</s1>
<s2>Düsseldorf</s2>
<s3>DEU</s3>
<sZ>23 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Düsseldorf</region>
<settlement type="city">Düsseldorf</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dohner, Hartmut" sort="Dohner, Hartmut" uniqKey="Dohner H" first="Hartmut" last="Döhner">Hartmut Döhner</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Universitätsklinikum Ulm</s1>
<s2>Ulm</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Ulm</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dohner, Konstanze" sort="Dohner, Konstanze" uniqKey="Dohner K" first="Konstanze" last="Döhner">Konstanze Döhner</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Universitätsklinikum Ulm</s1>
<s2>Ulm</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Ulm</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Blood</title>
<title level="j" type="abbreviated">Blood</title>
<idno type="ISSN">0006-4971</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Blood</title>
<title level="j" type="abbreviated">Blood</title>
<idno type="ISSN">0006-4971</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acute myelogenous leukemia</term>
<term>Genetics</term>
<term>Germany</term>
<term>Hematology</term>
<term>Lesion</term>
<term>Secondary</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Secondaire</term>
<term>Génétique</term>
<term>Lésion</term>
<term>Leucémie aiguë myéloblastique</term>
<term>Allemagne</term>
<term>Hématologie</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Allemagne</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Génétique</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">In this study, we evaluated the impact of secondary genetic lesions in acute myeloid leukemia (AML) with inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBFB-MYH11. We studied 176 patients, all enrolled on prospective treatment trials, for secondary chromosomal aberrations and mutations in N-IKRAS, KIT, FLT3, and JAK2 (V617F) genes. Most frequent chromosomal aberrations were trisomy 22 (18%) and trisomy 8 (16%). Overall, 84% of patients harbored at least 1 gene mutation, with RAS being affected in 53% (45% NRAS; 13% KRAS) of the cases, followed by KIT(37%) and FLT3(17%; FLT3-TKD [14%], FLT3-ITD [5%]). None of the secondary genetic lesions influenced achievement of complete remission. In multivariable analyses, KIT mutation (hazard ratio [HR] = 1.67; P = .04]<sub>,</sub>
 log<sub>10</sub>
(WBC) (HR = 1.33; P = .02), and trisomy 22 (HR = 0.54; P = .08) were relevant factors for relapse-free survival; for overall survival, FLT3 mutation (HR = 2.56; P = .006), trisomy 22 (HR = 0.45; P = .07), trisomy 8 (HR = 2.26; P = .02), age (difference of 10 years, HR = 1.46; P = .01), and therapy-related AML (HR = 2.13; P = .14) revealed as prognostic factors. The adverse effects of KIT and FLT3 mutations were mainly attributed to exon 8 and tyrosine kinase domain mutations, respectively. Our large study emphasizes the impact of both secondary chromosomal aberrations as well as gene mutations for outcome in AML with inv(16)/t (16;16).</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
</country>
<region><li>Bade-Wurtemberg</li>
<li>Basse-Saxe</li>
<li>Bavière</li>
<li>District de Cologne</li>
<li>District de Düsseldorf</li>
<li>District de Fribourg-en-Brisgau</li>
<li>District de Haute-Bavière</li>
<li>District de Karlsruhe</li>
<li>District de Tübingen</li>
<li>Rhénanie-du-Nord-Westphalie</li>
<li>Schleswig-Holstein</li>
</region>
<settlement><li>Bonn</li>
<li>Düsseldorf</li>
<li>Fribourg-en-Brisgau</li>
<li>Hanovre</li>
<li>Karlsruhe</li>
<li>Kiel</li>
<li>Munich</li>
<li>Tübingen</li>
<li>Ulm</li>
</settlement>
<orgName><li>Université Louis-et-Maximilien de Munich</li>
</orgName>
</list>
<tree><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Paschka, Peter" sort="Paschka, Peter" uniqKey="Paschka P" first="Peter" last="Paschka">Peter Paschka</name>
</region>
<name sortKey="Bullinger, Lars" sort="Bullinger, Lars" uniqKey="Bullinger L" first="Lars" last="Bullinger">Lars Bullinger</name>
<name sortKey="Corbacioglu, Andrea" sort="Corbacioglu, Andrea" uniqKey="Corbacioglu A" first="Andrea" last="Corbacioglu">Andrea Corbacioglu</name>
<name sortKey="Dohner, Hartmut" sort="Dohner, Hartmut" uniqKey="Dohner H" first="Hartmut" last="Döhner">Hartmut Döhner</name>
<name sortKey="Dohner, Konstanze" sort="Dohner, Konstanze" uniqKey="Dohner K" first="Konstanze" last="Döhner">Konstanze Döhner</name>
<name sortKey="Gaidzik, Verena I" sort="Gaidzik, Verena I" uniqKey="Gaidzik V" first="Verena I." last="Gaidzik">Verena I. Gaidzik</name>
<name sortKey="Ganser, Arnold" sort="Ganser, Arnold" uniqKey="Ganser A" first="Arnold" last="Ganser">Arnold Ganser</name>
<name sortKey="Gotze, Katharina" sort="Gotze, Katharina" uniqKey="Gotze K" first="Katharina" last="Götze">Katharina Götze</name>
<name sortKey="Held, Gerhard" sort="Held, Gerhard" uniqKey="Held G" first="Gerhard" last="Held">Gerhard Held</name>
<name sortKey="Horst, Heinz August" sort="Horst, Heinz August" uniqKey="Horst H" first="Heinz-August" last="Horst">Heinz-August Horst</name>
<name sortKey="Juan Du" sort="Juan Du" uniqKey="Juan Du" last="Juan Du">JUAN DU</name>
<name sortKey="Kayser, Sabine" sort="Kayser, Sabine" uniqKey="Kayser S" first="Sabine" last="Kayser">Sabine Kayser</name>
<name sortKey="Kirchen, Heinz" sort="Kirchen, Heinz" uniqKey="Kirchen H" first="Heinz" last="Kirchen">Heinz Kirchen</name>
<name sortKey="Kohne, Claus Henning" sort="Kohne, Claus Henning" uniqKey="Kohne C" first="Claus-Henning" last="Köhne">Claus-Henning Köhne</name>
<name sortKey="Krauter, Jurgen" sort="Krauter, Jurgen" uniqKey="Krauter J" first="Jürgen" last="Krauter">Jürgen Krauter</name>
<name sortKey="Kundgen, Andrea" sort="Kundgen, Andrea" uniqKey="Kundgen A" first="Andrea" last="Kündgen">Andrea Kündgen</name>
<name sortKey="Lubbert, Michael" sort="Lubbert, Michael" uniqKey="Lubbert M" first="Michael" last="Lübbert">Michael Lübbert</name>
<name sortKey="Ringhoffer, Mark" sort="Ringhoffer, Mark" uniqKey="Ringhoffer M" first="Mark" last="Ringhoffer">Mark Ringhoffer</name>
<name sortKey="Rummel, Mathias" sort="Rummel, Mathias" uniqKey="Rummel M" first="Mathias" last="Rummel">Mathias Rummel</name>
<name sortKey="Salih, Helmut R" sort="Salih, Helmut R" uniqKey="Salih H" first="Helmut R." last="Salih">Helmut R. Salih</name>
<name sortKey="Schlegelberger, Brigitte" sort="Schlegelberger, Brigitte" uniqKey="Schlegelberger B" first="Brigitte" last="Schlegelberger">Brigitte Schlegelberger</name>
<name sortKey="Schlenk, Richard F" sort="Schlenk, Richard F" uniqKey="Schlenk R" first="Richard F." last="Schlenk">Richard F. Schlenk</name>
<name sortKey="Sp Th, Daniela" sort="Sp Th, Daniela" uniqKey="Sp Th D" first="Daniela" last="Sp Th">Daniela Sp Th</name>
<name sortKey="Von Lilienfeld Toal, Marie" sort="Von Lilienfeld Toal, Marie" uniqKey="Von Lilienfeld Toal M" first="Marie" last="Von Lilienfeld-Toal">Marie Von Lilienfeld-Toal</name>
<name sortKey="Wattad, Mohammed" sort="Wattad, Mohammed" uniqKey="Wattad M" first="Mohammed" last="Wattad">Mohammed Wattad</name>
</country>
</tree>
</affiliations>
</record>

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Secondary genetic lesions in acute myeloid leukemia with inv(16) or t(16;16): a study of the German-Austrian AML Study Group (AMLSG)

Secondary genetic lesions in acute myeloid leukemia with inv(16) or t(16;16): a study of the German-Austrian AML Study Group (AMLSG)

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